Have an order or account question, find answers in our Online Support articles. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * MATERIAL SAFETY DATA SHEET. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. : 160182 Date Approved: 05/25/2010 Revision No. It works as a moisture sponge and permits the controlled growth of spheroids. : CL-611NF Date Approved: 01/13/2010. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Learn about FMC's industry leading goal of net-zero emissions by 2035. MCC helps in the formation of spheres because of its . Catalog Number 102331. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. 4. Microcrystalline Cellulose / Avicel PH-102. Are you looking for information about products and services by region? 4 0 obj Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . HMo@9, U Q!R/1*;` ). Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Validity Area. Product Name Cellulose microcrystalline. Created Date: 2/10/2020 8:51:41 PM . Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . EMCOCEL XLM 90. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. q86@on$^X_HuH;3` SUBSTANCE IDENTIFICATION 1.1. These grades have particle sizes ranging from <30 to approximately 200. Microcrystalline Cellulose / Avicel PH-102. In extrusion-spheronisation, it is the excipient of choice. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC The short-term limit for total inhalable dust is 20 mg/m3. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). . Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. EMCOCEL 90 M. 130. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Avicel PH-101. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. 1 0 obj Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. (Microcrystalline Cellulose Market Pr. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. stream Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. /Type/Page Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Molecular weight: Not Applicable 1.5. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe It is available in different grades and particle sizes. Protect them from sunshine or rain. Well-recognized product that can do it all. No. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. It is also used in plaque assays for counting. stream CAS #: 9004-34-6 . >> Combines good flow and high compactibility. 1 0 obj This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. ChemicalBook. << By producing Avicel . All Rights Reserved. AVICEL RC 581. MATERIAL SAFETY DATA SHEET Version: 1.0 1. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . }o]X4]. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. 5 0 obj There may be more fiber in your food than you realized. Explore how you can develop your career and bring your creative ideas to life at IFF. Avicel PC 611 (FMC Biopolymer) Supplied by. Wu, K. Zuurman, H.W. <> The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. 2 0 obj Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com [email protected] EMERGENCY RESPONSE NUMBER endobj !(!0*21/*.-4;[email protected]? if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. endstream on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. ( {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. However, if handling bulk powders, observance of appropriate safeguards is recommended. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? The data shown below apply only to Avicel PH 101. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. All Rights Reserved. [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. PDF (2.77 mb) 2021 FMC Sustainability Report. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Safety Data Sheet (SDS) Viewer. SCMm_>x^O9l (n. 4 0 obj LOT #: Available upon request. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. [FMC Study Number I92-1464]. Production of Pharmaceutical Grade Microcrystalline Cellulose. Meet our leadership team. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. If breathing is difficult or if . Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . No. We know that our customers need to provide reliable and consistent products to their patients. % Magazine: Material safety data sheet - FMC Corporation. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. We can send by Fedex, by ship or by plane according to international rules. Biologicals by FMC. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Are you sure you want to delete your template? TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. % Safety Data Sheet for Cellulose microcrystalline 102331. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. q9;v80 GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Quantity: 1 700 kgs. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Avicel Microcrystalline Cellulose Physical Properties. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ INCI. stream LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Cellulose microcrystalline for column chromatography. Browse Avicel PH-101 and related products at MilliporeSigma. undefined. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. q9;v80q>jZ We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Watch Now. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. 0.25 - 0.37. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. However, consumption of large quantities of the material may have a laxative effect. common form is used in vitamin supplements or tablets. It is also inert and biocompatible. Test Data Available. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. 1.3. xv}O2' H~KEe9>G/,:9\i It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. endobj Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. PDF (28.38 mb) 2022 Corporate Fact Sheet. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Your file is uploaded and ready to be published. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . FMC, JRS and Mingtai were estimated to hold for . Eur., JPE . Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. };khd5x=fr Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Unique functionality for a broad range of pharmaceutical applications. If you are already a ChemPoint customer then sign up for access to our online ordering website. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. P}MFbN#[>r(y Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Superior Performance: Provides excellent water uptake and rapid swelling . FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . 130. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. . Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. We respect your privacy FMC Privacy Policy. %PDF-1.4 !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b /Parent 3 0 R If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Home. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. Manufacturer: FMC BioPolymer. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Microcrystalline Cellulose NF. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. <> Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. MATERIAL SAFETY DATA SHEET. Avicel Microcrystalline Cellulose: Chemical Identifiers. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . Revision No. POLYOX resins are nonionic polyethylene oxide solubility polymers. 3 0 obj Microcrystalline cellulose is a commonly used excipient in the . 6 0 obj pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Microcrystalline Cellulose; Cellulose; Functions. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. gac74 [#B6`Wnw7 (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Avicel PC 611 (FMC Biopolymer) . JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Manufactured by: China . Delivering efficient and robust formulations. (1962). Find answers in our support articles. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) [email protected] (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. CAS #: 9004-34-6 1.6. Thus, Avicel contributes no or very few calories to the food system. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. In 1964 FMC, Corporation . The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Chemical Formula: (C6H10O5)n 1.4. MSDS Ref. Medium size standard MCC grade, suited for the majority of directly compressible actives. CAS #: 9004-34-6 This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. <> 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Cellulose microcrystalline. % ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. %PDF-1.3 X\o^ Microcrystalline cellulose -The oldest polymer finds new industrial uses,. It is . II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. : 5. FMC Corporation. Revision No. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. CAS 9004-34-6, pH 5 - 7.5. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. stream 9,LL!z Truly distinctive drug delivery solutions. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. <> The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. B;vLZpHU%ChUyD+[ Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Buy Chemicals. Heavy metals, % NMT 0.001 The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. *r_ *?~4$ &0Y# Trademarks: Avicel PH-102. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM A family of polysaccharide products that allow distinctive drug delivery solutions. The table below shows the most common physicochemical parameters of this raw material. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Microcrystalline Cellulose E460 MSDS 1. Quick Links. EINECS #: 232-674-9 1.7. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with .
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